Preventing Alzheimer's. Is It About to Become a Reality?

Scientists at the Center for Alzheimer's Research and Treatment at Brigham and Women's Hospital in Boston are about to embark on one of the most anticipated, longest Alzheimer's drug studies in history. The study will be conducted on 1,000 subjects over a three year period at a cost of well more than $100 million. They are just hoping they can find enough people.

The folks they are looking for must already have amyloid building up in their brains but aren't currently showing any symptoms of Alzheimer's. The idea is to treat the amyloid proteins with an experimental drug before they become toxic and turn into the dreaded plaques and tangles that scientists have been battling for years in the fight against Alzheimer's disease.

In order to find the 1,000 participants, the directors of the study anticipate that they will  need to screen about 5,000 people throughout the United States and Canada. They are also exploring the possibility of a site in Australia. To qualify, participants in the study must be at least 65 yrs old, willing to take a drug or placebo, willing to get a genetics test, willing to have a brain scan done twice a year, and willing to answer all kinds of questions about every facet of how they live their lives.

In previous clinical trials, the drug being tested showed promise in slowing the effects of mid-stage Alzheimer's symptoms. This success, in addition to the size and scope of the study, has turned a number of heads in the scientific community who will be watching the results very carefully.

One of the frustrating aspects of dealing with the disease is that most of the work is being done in the proverbial rear-view mirror. Since there is no way to predict where the disease will appear, scientists are forced to study patients who have already begun to manifest symptoms. The hope of this new study is that it will give doctors a glimpse at not only the effectiveness of the new drug but also a window into the way the disease develops. Perhaps it will at last show them how to prevent the disease from developing entirely. Perhaps.

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